May 2014:
Since I was hospitalized for the first time a year ago, I've had a roller coaster with medications.
Medications I cannot tolerate, that made my symptoms worse, or that have caused allergic reactions or adverse side effects:
Celexa. worked, then didn't and caused horrible side effects.
Temzepam: worked, but also caused bad side effects that I tolerated for way too long because I needed to sleep to be able to work. I wish I had known better.
Cymbalta: tipped me from depressed to bipolar, and had lots of crappy side effects like no REM sleep.
Welbutrin: teeth grinding, nail-biting, acute manic symptoms, intense anxiety attacks.
Lithium: worked for a while, then, blam! hives and manic attacks, ugh.
Depakote: felt like being on the SSRIs again: no sleep, constipation, dreary mood, no apparent benefit.
Seroquel . This one helped stabilize the manic symptoms, and helped me sleep (wonderful!) but was hellish on my metabolism and did not helped the depression. I slept, but I couldn't concentrate, remember or focus well when I was awake; I am tired all the time, I gained 30 lbs in 3 months (!) and I felt shaky and anxious with every savage blood-sugar change. Scary: I started to get symptoms of neuropathy in my legs, and this medication can make you diabetic. Worst is the fact that the depression did not go away, even though the panic attacks did. The doctor said we should step down and step off while I started a new mood stabilizer.
So, on to the next:
oxcarbazepine, an anti-seizure medication also known as Trileptal (a close relative of Tegretol or carbamazepine). Some of the suckier side-effects are not an issue for me (don't need to worry about birth control pills), but I will need to have my blood levels monitored and watch out for nasty and potentially fatal rash.
So far, so good. The neuropathy disappeared right away, as did the daily mood swings. Trileptal has not caused any new side effects. I'm sleeping reasonably well. My appetite and digestion are normal. No manic symptoms. Still with the bad depression...but not as bad. I can now read a whole book again, and I have returned to learning: Japanese and Korean.
I still experience periodic flashes of intense, gruesome, horrific depression that make the future seem uniformly bleak and make me doubt my capacity to resist. But they are not lasting as long. This is progress.